Intervention of alpha-lipoic acid ameliorates methotrexate-induced oxidative stress and genotoxicity: A study in rat intestine

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ID: 271564
2010
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Abstract
Methotrexate (MTX) is an anti-metabolite, widely used in the cancer chemotherapy and rheumatoid arthritis. However, its long-term clinical use is restricted on account of its severe intestinal toxicity. The present study was aimed to investigate the intestinal toxicity of MTX and the possible protec …
Reference Key
vp2010chemico-biologicalintervention Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Dadhania VP;Tripathi DN;Vikram A;Ramarao P;Jena GB;;
Journal Chemico-biological interactions
Year 2010
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/19900424
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't male Rats Sprague-Dawley malondialdehyde / metabolism oxidative stress / drug effects dna damage in situ nick-end labeling antimetabolites methotrexate / toxicity* tumor suppressor protein p53 / metabolism intestines / drug effects* intestines / pathology comet assay pmid:19900424 doi:10.1016/j.cbi.2009.10.020 v p dadhania d n tripathi g b jena alkaline phosphatase / metabolism antineoplastic / toxicity* glutathione / metabolism thioctic acid / pharmacology*

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