Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mouse liver preparations
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ID: 271545
1984
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Abstract
Using a mouse liver microsomal preparation, it was found that the heterocyclic ring system of MPTP underwent an initial α-oxidation to give chemically reactive metabolites that may be associated with the induction of Parkinsonism by MPTP. Subsequent oxidative metabolic transformations of these intermediates were found to give a lactam metabolite and a pyridone metabolite that potentially may interact with the neurotransmitter system.
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| Authors | John K. Baker,Ronald F. Borne,W. Marvin Davis,I.Wade Waters;John K. Baker;Ronald F. Borne;W. Marvin Davis;I.Wade Waters; |
| Journal | Biochemical and biophysical research communications |
| Year | 1984 |
| DOI |
10.1016/0006-291x(84)90566-7
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