β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation

Clicks: 261
ID: 271483
2011
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Abstract
Although deregulation of the Wnt signalling pathway has been implicated in urothelial cell carcinoma (UCC), the functional significance is unknown. To test its importance, we have targeted expression of an activated form of β-catenin to the urothelium of transgenic mice using Cre-Lox technology (Uro …
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Authors Ahmad I;Morton JP;Singh LB;Radulescu SM;Ridgway RA;Patel S;Woodgett J;Winton DJ;Taketo MM;Wu XR;Leung HY;Sansom OJ;;
Journal Oncogene
Year 2011
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20818428
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female male Proto-Oncogene Proteins c-akt / metabolism Cohort Studies carcinoma cell proliferation cell transformation sequence deletion beta catenin / metabolism* phosphatidylinositol 3-kinases / metabolism hyperplasia / chemically induced wnt proteins / metabolism neoplastic / metabolism* pten phosphohydrolase / metabolism* pmid:20818428 pmc3044461 doi:10.1038/onc.2010.399 i ahmad j p morton o j sansom adenomatous polyposis coli protein / genetics papillary / metabolism* proto-oncogene proteins c-akt / analysis tor serine-threonine kinases / metabolism urinary bladder / metabolism urinary bladder neoplasms / chemically induced* urothelium / metabolism

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