A transgenic model to analyze the immunoregulatory role of IL-10 secreted by antigen-presenting cells

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ID: 271438
1999
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Abstract
IL-10 is a cytokine secreted by a wide variety of cells type that has pleiotropic stimulatory and suppressive activities on both lymphoid and myeloid cells in vitro. To analyze the consequences of high IL-10 secretion by APCs in immune responses, we produced transgenic mice expressing human IL-10 di …
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Authors Groux H;Cottrez F;Rouleau M;Mauze S;Antonenko S;Hurst S;McNeil T;Bigler M;Roncarolo MG;Coffman RL;;
Journal Journal of immunology (Baltimore, Md. : 1950)
Year 1999
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/9973435
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice Inbred C57BL animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't polymerase chain reaction Inbred BALB C Base Sequence transgenic recombinant proteins lymphocyte activation t-lymphocytes / immunology up-regulation inbred dba dna primers / genetics interleukin-10 / metabolism monocytes / immunology b-lymphocytes / immunology pmid:9973435 h groux f cottrez r l coffman antigen-presenting cells / immunology* interferon-gamma / pharmacology interleukin-10 / genetics interleukin-10 / immunology* leishmania major / immunology leishmania major / pathogenicity listeria monocytogenes / immunology listeria monocytogenes / pathogenicity mast-cell sarcoma / immunology ovalbumin / immunology

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