Aflatoxin B1 modulates the expression of phenotypic markers and cytokines by splenic lymphocytes of male F344 rats

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ID: 271437
2014
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Abstract
Aflatoxin B1 (AFB1) is immunotoxic to animals and a suspected immunosuppressant in humans. In this study, we investigated the effects of AFB1 on splenic lymphocyte phenotypes and the inflammatory cytokine expression in male F344 rats. Exposure of animals to AFB1 [5-75 µg kg(-1) body weight (BW)] for …
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Authors Qian G;Tang L;Guo X;Wang F;Massey ME;Su J;Guo TL;Williams JH;Phillips TD;Wang JS;;
Journal journal of applied toxicology : jat
Year 2014
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/23508487
Keywords
Administration National Center for Biotechnology Information NCBI NLM MEDLINE animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't male N.I.H. Extramural Rats phenotype dose-response relationship drug flow cytometry oral lymphocytes / immunology spleen / immunology cytokines / biosynthesis* killer cells t-lymphocyte subsets / immunology b-lymphocytes / immunology pmid:23508487 pmc4268892 doi:10.1002/jat.2866 guoqing qian lili tang jia-sheng wang aflatoxin b1 / toxicity* b-lymphocytes / drug effects environmental pollutants / toxicity* natural / drug effects natural / immunology lymphocytes / drug effects* inbred f344 spleen / drug effects* t-lymphocyte subsets / drug effects

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