Interrogating open issues in cancer precision medicine with patient-derived xenografts - Nature Reviews Cancer

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ID: 271412
2017
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Abstract
This Opinion article discusses progress and challenges in using patient-derived xenograft (PDX) models in cancer precision medicine. It is primarily co-authored by members of the EurOPDX Consortium and as such highlights the merits of shared PDX resources.
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Authors Byrne, Annette T.;Alférez, Denis G.;Amant, Frédéric;Annibali, Daniela;Arribas, Joaquín;Biankin, Andrew V.;Bruna, Alejandra;Budinská, Eva;Caldas, Carlos;Chang, David K.;Clarke, Robert B.;Clevers, Hans;Coukos, George;Dangles-Marie, Virginie;Eckhardt, S. Gail;Gonzalez-Suarez, Eva;Hermans, Els;Hidalgo, Manuel;Jarzabek, Monika A.;de Jong, Steven;Jonkers, Jos;Kemper, Kristel;Lanfrancone, Luisa;Mælandsmo, Gunhild Mari;Marangoni, Elisabetta;Marine, Jean-Christophe;Medico, Enzo;Norum, Jens Henrik;Palmer, Héctor G.;Peeper, Daniel S.;Pelicci, Pier Giuseppe;Piris-Gimenez, Alejandro;Roman-Roman, Sergio;Rueda, Oscar M.;Seoane, Joan;Serra, Violeta;Soucek, Laura;Vanhecke, Dominique;Villanueva, Alberto;Vinolo, Emilie;Bertotti, Andrea;Trusolino, Livio;Byrne, Annette T.;Alférez, Denis G.;Amant, Frédéric;Annibali, Daniela;Arribas, Joaquín;Biankin, Andrew V.;Bruna, Alejandra;Budinská, Eva;Caldas, Carlos;Chang, David K.;Clarke, Robert B.;Clevers, Hans;Coukos, George;Dangles-Marie, Virginie;Eckhardt, S. Gail;Gonzalez-Suarez, Eva;Hermans, Els;Hidalgo, Manuel;Jarzabek, Monika A.;de Jong, Steven;Jonkers, Jos;Kemper, Kristel;Lanfrancone, Luisa;Mælandsmo, Gunhild Mari;Marangoni, Elisabetta;Marine, Jean-Christophe;Medico, Enzo;Norum, Jens Henrik;Palmer, Héctor G.;Peeper, Daniel S.;Pelicci, Pier Giuseppe;Piris-Gimenez, Alejandro;Roman-Roman, Sergio;Rueda, Oscar M.;Seoane, Joan;Serra, Violeta;Soucek, Laura;Vanhecke, Dominique;Villanueva, Alberto;Vinolo, Emilie;Bertotti, Andrea;Trusolino, Livio;
Journal Nature Reviews Cancer
Year 2017
DOI
doi:10.1038/nrc.2016.140
URL
https://doi.org/10.1038/nrc.2016.140
Keywords
cancer therapy cancer models tumour biomarkers tumour immunology

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