Evaluation of intravenous zanamivir against experimental influenza A (H5N1) virus infection in cynomolgus macaques

Clicks: 234
ID: 271357
2008
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Abstract
We investigated the prophylactic and therapeutic efficacy of an intravenous (IV) formulation of zanamivir in a macaque infection model for highly pathogenic influenza A (H5N1) virus. Antiviral efficacy was dose-dependent, with no reduction in viral load observed at 2 mg/kg, but a significant reducti …
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Authors Stittelaar KJ;Tisdale M;van Amerongen G;van Lavieren RF;Pistoor F;Simon J;Osterhaus AD;;
Journal Antiviral research
Year 2008
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/18647621
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals humans pubmed abstract nih national institutes of health national library of medicine male Disease Models Animal Comparative Study influenza human / drug therapy* human / prevention & control antiviral agents / administration & dosage* influenza a virus human / virology h5n1 subtype / physiology pmid:18647621 doi:10.1016/j.antiviral.2008.06.014 k j stittelaar m tisdale a d m e osterhaus h5n1 subtype / drug effects* macaca zanamivir / administration & dosage*

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