A new secreted protein that binds to Wnt proteins and inhibits their activities

بروتين مُفرَز جديد يرتبط ببروتينات Wnt ويُثبِّط أنشطتها

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ID: 271301
1999
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Abstract
The Wnt proteins constitute a large family of extracellular signalling molecules that are found throughout the animal kingdom and are important for a wide variety of normal and pathological developmental processes. Here we describe Wnt-inhibitory factor-1 (WIF-1), a secreted protein that binds to Wn …
تُشكّل بروتينات Wnt عائلةً كبيرة من جزيئات التأشير خارج الخلوية الموجودة في شتى أرجاء المملكة الحيوانية، والتي تؤدي دوراً مهماً في طيف واسع من العمليات النمائية الطبيعية والمرضية. ونصف هنا العامل المُثبّط لـ Wnt-1 ‏(WIF-1)، وهو بروتين مُفرَز يرتبط بـ Wn …
Reference Key
jc1999naturea Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hsieh JC;Kodjabachian L;Rebbert ML;Rattner A;Smallwood PM;Samos CH;Nusse R;Dawid IB;Nathans J;;
Journal Nature
Year 1999
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10201374
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't amino acid sequence Immunoglobulin G / metabolism Molecular Sequence Data sequence homology amino acid recombinant fusion proteins / genetics carrier proteins / genetics cricetinae signal transduction protein binding recombinant fusion proteins / metabolism carrier proteins / metabolism* adaptor proteins signal transducing cho cells drosophila proteins* xenopus wnt proteins repressor proteins* proto-oncogene proteins / metabolism* zebrafish intercellular signaling peptides and proteins xenopus proteins zebrafish proteins* intracellular signaling peptides and proteins wnt1 protein carrier proteins / isolation & purification pmid:10201374 doi:10.1038/18899 j c hsieh l kodjabachian j nathans extracellular matrix proteins immunoglobulin g / genetics proto-oncogene proteins / antagonists & inhibitors

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