Study of Drug-Protein Binding by Affinity Chromatography: Interaction of Bovine Serum Albumin and Salicylic Acid
Clicks: 209
ID: 271275
1978
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Star Article
30.0
/100
209 views
28 readers
AI Quality Assessment
Not analyzed
Readership in this journal
StarRanked #35 of 59 articles by views in journal of pharmaceutical sciences
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
The affinity chromatographic technique was used to study the interaction of bovine serum albumin and salicylic acid at 3.3 ± 1.1°. Beaded agarose gel, on which the albumin was immobilized by covalent linkage, was packed in a column as an affinity adsorbent. Frontal analysis was performed on this column to evaluate the binding parameters for the interaction. The effect of albumin immobilization on drug binding was investigated by comparing the binding parameters of two affinity adsorbents, directly coupled albumin and albumin coupled through a spacer arm. The latter mode of attachment gave binding characteristics comparable to those of the soluble albumin. The method is simple and precise. The affinity adsorbent can be used repeatedly for many months for various drugs, including those that do not diffuse through dialysis membranes.
| Reference Key |
fujimqto1978journalstudy
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Naomi I. Nakano,Takayuki Oshio,Yukio Fujimoto,Takashi Amiya,Yukio Fujimqto;Naomi I. Nakano;Takayuki Oshio;Yukio Fujimoto;Takashi Amiya;Yukio Fujimqto; |
| Journal | journal of pharmaceutical sciences |
| Year | 1978 |
| DOI |
10.1002/jps.2600670737
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.