The CBP co-activator is a histone acetyltransferase

يُعدّ المنشط المساعد CBP ناقلة أسيتيل الهيستون.

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ID: 271246
1970
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Abstract
The CBP protein acts as a transcriptional adaptor for many different transcription factors by directly contacting DNA-bound activators. One mechanism by which CBP is thought to stimulate transcription is by recruiting the histone acetyltransferase (HAT) P/CAF to the promoter. Here we show that CBP h …
يعمل بروتين CBP كمحوّل نسخي للعديد من عوامل النسخ المختلفة من خلال الاتصال المباشر بالمُنشِّطات المرتبطة بالحمض النووي (DNA). وتتمثل إحدى الآليات التي يُعتقد أن بروتين CBP يُحفز النسخ من خلالها في استقطاب إنزيم ناقلة أسيتيل الهيستون (HAT) P/CAF إلى المُحفِّز. ونُبيّن هنا أن بروتين CBP h …
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Authors Bannister AJ;Kouzarides T;;
Journal Nature
Year 1970
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