Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1

Clicks: 408
ID: 271153
1999
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Abstract
Expression of the DMP1 transcription factor, a cyclin D-binding Myb-like protein, induces growth arrest in mouse embryo fibroblast strains but is devoid of antiproliferative activity in primary diploid fibroblasts that lack the ARF tumor suppressor gene. DMP1 binds to a single canonical recognition …
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Authors Inoue K;Roussel MF;Sherr CJ;;
Journal Proceedings of the National Academy of Sciences of the United States of America
Year 1999
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/10097151
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice Kidney animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't protein biosynthesis P.H.S. Cells Cultured cell line Genes genetic* 3T3 Cells Transcription Factors / metabolism* Base Sequence Molecular Sequence Data Promoter Regions Recombinant Fusion Proteins / biosynthesis gene expression regulation / drug effects proteins / genetics* embryo recombinant proteins / biosynthesis transfection cell division / drug effects fibroblasts / cytology fibroblasts / physiology cell cycle / drug effects mammalian M F Roussel Tumor Suppressor Protein p14ARF tumor suppressor protein p53 / metabolism k inoue c j sherr pmid:10097151 pmc22408 doi:10.1073/pnas.96.7.3993 cell cycle / physiology* cycloheximide / pharmacology tumor suppressor*

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