miRNAs: novel regulators of autoimmunity-mediated pancreatic β-cell destruction in type 1 diabetes - Cellular & Molecular Immunology

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2017
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Abstract
MicroRNAs (miRNAs) are a series of conserved, short, non-coding RNAs that modulate gene expression in a posttranscriptional manner. miRNAs are involved in almost every physiological and pathological process. Type 1 diabetes (T1D) is an autoimmune disease that is the result of selective destruction of pancreatic β-cells driven by the immune system. miRNAs are also important participants in T1D pathogenesis. Herein, we review the most recent data on the potential involvement of miRNAs in T1D. Specifically, we focus on two aspects: the roles of miRNAs in maintaining immune homeostasis and regulating β-cell survival and/or functions in T1D. We also discuss circulating miRNAs as potent biomarkers for the diagnosis and prediction of T1D and investigate potential therapeutic approaches for this disease.
Reference Key
ying2017cellularmirnas: Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zheng, Ying;Wang, Zhen;Zhou, Zhiguang;Zheng, Ying;Wang, Zhen;Zhou, Zhiguang;
Journal Cellular & molecular immunology
Year 2017
DOI
doi:10.1038/cmi.2017.7
URL
https://dx.doi.org/10.1038/cmi.2017.7
Keywords
Microbiology vaccine immunology biomedicine antibodies medical microbiology general

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