Structural basis for the activation of cholera toxin by human ARF6-GTP

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ID: 271079
2005
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Abstract
The Vibrio cholerae bacterium causes devastating diarrhea when it infects the human intestine. The key event is adenosine diphosphate (ADP)-ribosylation of the human signaling protein GSalpha, catalyzed by the cholera toxin A1 subunit (CTA1). This reaction is allosterically activated by human ADP-ri …
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Authors O'Neal CJ;Jobling MG;Holmes RK;Hol WG;;
Journal Science (New York, N.Y.)
Year 2005
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/16099990
Keywords
Evolution National Center for Biotechnology Information NCBI NLM MEDLINE Molecular humans pubmed abstract nih national institutes of health national library of medicine models research support non-u.s. gov't u.s. gov't N.I.H. Extramural amino acid sequence P.H.S. Molecular Sequence Data protein conformation protein binding protein structure binding sites secondary x-ray crystallography pmid:16099990 doi:10.1126/science.1113398 claire j o'neal michael g jobling wim g j hol adp-ribosylation factors / chemistry* adp-ribosylation factors / genetics adp-ribosylation factors / metabolism* cholera toxin / chemistry* cholera toxin / genetics cholera toxin / metabolism* dimerization guanosine diphosphate / metabolism guanosine triphosphate / chemistry* guanosine triphosphate / metabolism* hydrophobic and hydrophilic interactions nad / metabolism

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