The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2

Clicks: 301
ID: 271016
1998
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Abstract
The two distinct proteins encoded by the CDKN2A locus are specified by translating the common second exon in alternative reading frames. The product of the alpha transcript, p16(INK4a), is a recognized tumour suppressor that induces a G1 cell cycle arrest by inhibiting the phosphorylation of the ret …
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Authors Stott FJ;Bates S;James MC;McConnell BB;Starborg M;Brookes S;Palmero I;Ryan K;Hara E;Vousden KH;Peters G;;
Journal the embo journal
Year 1998
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/9724636
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE genetic gene expression regulation humans pubmed abstract nih national institutes of health national library of medicine models research support non-u.s. gov't u.s. gov't amino acid sequence Comparative Study P.H.S. neoplastic* Molecular Sequence Data sequence homology amino acid protein binding proteins / genetics feedback cyclin-dependent kinase inhibitor p16 / genetics nuclear proteins* proteins / metabolism* Tumor Suppressor Protein p14ARF proto-oncogene proteins / metabolism* proto-oncogene proteins c-mdm2 tumor suppressor protein p53 / metabolism* cell cycle / physiology pmid:9724636 pmc1170828 doi:10.1093/emboj/17.17.5001 f j stott s bates g peters alternative splicing* cyclin-dependent kinase inhibitor p16 / metabolism*

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