The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer

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ID: 271002
2005
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Abstract
Wnt glycoproteins regulate homeostasis and development by binding to membrane Frizzled-LRP5/6 receptor complexes. Wnt signaling includes a canonical pathway involving cytosolic beta-catenin stabilization, nuclear translocation and gene regulation, acting as a co-activator of T-cell factor (TCF) prot …
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Authors González-Sancho JM;Aguilera O;García JM;Pendás-Franco N;Peña C;Cal S;García de Herreros A;Bonilla F;Muñoz A;;
Journal Oncogene
Year 2005
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15592505
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE gene expression regulation humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't Genes neoplastic* proteins / genetics* gene expression profiling* signal transduction homeostasis down-regulation transcription factor 7-like 2 protein Tumor Suppressor wnt proteins beta catenin helix-loop-helix motifs tcf transcription factors pmid:15592505 doi:10.1038/sj.onc.1208303 josé manuel gonzález-sancho oscar aguilera alberto muñoz colonic neoplasms / genetics* colonic neoplasms / pathology* cytoskeletal proteins / pharmacology* dna-binding proteins / pharmacology* intercellular signaling peptides and proteins / pharmacology trans-activators / pharmacology* transcription factors / pharmacology* wnt1 protein

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