Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion

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ID: 270949
2008
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Abstract
Replicated chromosomes are held together by the chromosomal cohesin complex from the time of their synthesis in S phase onward. This requires the replication fork-associated acetyl transferase Eco1, but Eco1's mechanism of action is not known. We identified spontaneous suppressors of the thermosensi …
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Authors Rolef Ben-Shahar T, Heeger S, Lehane C, East P, Flynn H, Skehel M, Uhlmann F
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Journal Science (New York, N.Y.)
Year 2008
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/18653893
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE genetic pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't DNA Nuclear Proteins / metabolism* mutation chromosomes dna replication cell cycle proteins / genetics cell cycle proteins / metabolism* nuclear proteins / genetics saccharomyces cerevisiae / genetics alleles nuclear proteins / chemistry chromosomal proteins acetyltransferases / genetics acetyltransferases / metabolism* fungal / physiology* fungal / metabolism dna repair cell cycle proteins / chemistry saccharomyces cerevisiae proteins / genetics saccharomyces cerevisiae / growth & development saccharomyces cerevisiae proteins / metabolism* saccharomyces cerevisiae / physiology* non-histone / genetics non-histone / metabolism* pmid:18653893 doi:10.1126/science.1157774 tom rolef ben-shahar sebastian heeger frank uhlmann acetylation acetyltransferases / chemistry chondroitin sulfate proteoglycans / chemistry chondroitin sulfate proteoglycans / genetics chondroitin sulfate proteoglycans / metabolism* chromatids / physiology* non-histone / chemistry protein subunits / chemistry protein subunits / genetics protein subunits / metabolism s phase saccharomyces cerevisiae proteins / chemistry suppression

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