Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

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ID: 270893
2001
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Abstract
CDKN2A (INK4a/ARF) is frequently disrupted in various types of human cancer, and germline mutations of this locus can confer susceptibility to melanoma and other tumours. However, because CDKN2A encodes two distinct cell cycle inhibitory proteins, p16INK4a and p14ARF (p19Arf in mice), the mechanism …
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Authors Krimpenfort P;Quon KC;Mooi WJ;Loonstra A;Berns A;;
Journal Nature
Year 2001
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/11544530
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female male Cells Cultured Genes genetic predisposition to disease* embryo proteins / genetics cell transformation neoplastic fibroblasts / physiology experimental / pathology cyclin-dependent kinase inhibitor p16 / genetics gene deletion point mutation ras Tumor Suppressor Protein p14ARF p16* pmid:11544530 doi:10.1038/35092584 p krimpenfort k c quon a berns 9 10-dimethyl-1 2-benzanthracene carcinogens cyclin-dependent kinase inhibitor p16 / physiology mammalian / cytology melanoma experimental / genetics* experimental / secondary

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