The diploid genome sequence of an Asian individual

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2008
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Abstract
Here we present the first diploid genome sequence of an Asian individual. The genome was sequenced to 36-fold average coverage using massively parallel sequencing technology. We aligned the short reads onto the NCBI human reference genome to 99.97% coverage, ...
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Authors Jun Wang, Wei Wang, Ruiqiang Li, Yingrui Li, Geng Tian, Laurie Goodman, Wei Fan, Junqing Zhang, Jun Li, Juanbin Zhang, Yiran Guo, Binxiao Feng, Heng Li, Yao Lu, Xiaodong Fang, Huiqing Liang, Zhenglin Du, Dong Li, Yiqing Zhao, Yujie Hu, Zhenzhen Yang, Hancheng Zheng, Ines Hellmann, Michael Inouye, John Pool, Xin Yi, Jing Zhao, Jinjie Duan, Yan Zhou, Junjie Qin, Lijia Ma, Guoqing Li, Zhentao Yang, Guojie Zhang, Bin Yang, Chang Yu, Fang Liang, Wenjie Li, Shaochuan Li, Dawei Li, Peixiang Ni, Jue Ruan, Qibin Li, Hongmei Zhu, Dongyuan Liu, Zhike Lu, Ning Li, Guangwu Guo, Jianguo Zhang, Jia Ye, Lin Fang, Qin Hao, Quan Chen, Yu Liang, Yeyang Su, A. san, Cuo Ping, Shuang Yang, Fang Chen, Li Li, Ke Zhou, Hongkun Zheng, Yuanyuan Ren, Ling Yang, Yang Gao, Guohua Yang, Zhuo Li, Xiaoli Feng, Karsten Kristiansen, Gane Ka-Shu Wong, Rasmus Nielsen, Richard Durbin, Lars Bolund, Xiuqing Zhang, Songgang Li, Huanming Yang, Jian Wang;Jun Wang;Wei Wang;Ruiqiang Li;Yingrui Li;Geng Tian;Laurie Goodman;Wei Fan;Junqing Zhang;Jun Li;Juanbin Zhang;Yiran Guo;Binxiao Feng;Heng Li;Yao Lu;Xiaodong Fang;Huiqing Liang;Zhenglin Du;Dong Li;Yiqing Zhao;Yujie Hu;Zhenzhen Yang;Hancheng Zheng;Ines Hellmann;Michael Inouye;John Pool;Xin Yi;Jing Zhao;Jinjie Duan;Yan Zhou;Junjie Qin;Lijia Ma;Guoqing Li;Zhentao Yang;Guojie Zhang;Bin Yang;Chang Yu;Fang Liang;Wenjie Li;Shaochuan Li;Dawei Li;Peixiang Ni;Jue Ruan;Qibin Li;Hongmei Zhu;Dongyuan Liu;Zhike Lu;Ning Li;Guangwu Guo;Jianguo Zhang;Jia Ye;Lin Fang;Qin Hao;Quan Chen;Yu Liang;Yeyang Su;A. san;Cuo Ping;Shuang Yang;Fang Chen;Li Li;Ke Zhou;Hongkun Zheng;Yuanyuan Ren;Ling Yang;Yang Gao;Guohua Yang;Zhuo Li;Xiaoli Feng;Karsten Kristiansen;Gane Ka-Shu Wong;Rasmus Nielsen;Richard Durbin;Lars Bolund;Xiuqing Zhang;Songgang Li;Huanming Yang;Jian Wang;
Journal Nature
Year 2008
DOI
10.1038/nature07484
URL
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716080/
Keywords
Internet databases National Center for Biotechnology Information NCBI NLM MEDLINE genetic animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't sequence alignment Comparative Study genome phenotype human / genetics* sensitivity and specificity Polymorphism genomics* jun wang consensus sequence alleles single nucleotide / genetics diploidy* pmid:18987735 pmc2716080 doi:10.1038/nature07484 wei wang jian wang asian continental ancestry group / genetics* genetic predisposition to disease / genetics haplotypes / genetics pan troglodytes / genetics

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