Identification of sequence changes in myosin II that adjust muscle contraction velocity

Clicks: 175
ID: 270752
2021
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Abstract
Heart and skeletal muscles of larger mammals contract more slowly than smaller ones. This study identifies amino acid changes in myosin isoforms that correlate with species size; mutating the residues in human β-myosin to match the rat sequence at these positions increased its in vitro velocity to that of the rat protein.
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Authors Chloe A. Johnson;Jake E. McGreig;Sarah T. Jeanfavre;Jonathan Walklate;Carlos D. Vera;Marta Farré;Daniel P. Mulvihill;Anthony J. Baines;Martin Ridout;Leslie A. Leinwand;Mark N. Wass;Michael A. Geeves;
Journal plos biology
Year 2021
DOI
10.1371/journal.pbio.3001248
URL
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001248
Keywords
phylogenetic analysis mammals protein sequencing muscle contraction amino acid analysis myosins cardiac muscles cardiomyopathies

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