Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb

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ID: 270670
2003
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Abstract
By conditional gene ablation in mice, we found that beta-catenin, an essential downstream effector of canonical Wnt signaling, is a key regulator of formation of the apical ectodermal ridge (AER) and of the dorsal-ventral axis of the limbs. By generation of compound mutants, we also show that beta-c …
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Authors Soshnikova N;Zechner D;Huelsken J;Mishina Y;Behringer RR;Taketo MM;Crenshaw EB;Birchmeier W;;
Journal genes & development
Year 2003
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/12923052
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't Comparative Study signal transduction* Receptors mutation transgenic trans-activators / metabolism* bone morphogenetic protein receptors type i mutant strains wnt proteins beta catenin cytoskeletal proteins / metabolism* proto-oncogene proteins / metabolism* protein-serine-threonine kinases / metabolism zebrafish proteins* trans-activators / genetics body patterning / genetics cytoskeletal proteins / genetics pmid:12923052 pmc196251 doi:10.1101/gad.263003 natalia soshnikova dietmar zechner walter birchmeier ectoderm / metabolism extremities / embryology* fibroblast growth factor 8 fibroblast growth factors / metabolism hindlimb / abnormalities limb deformities congenital / genetics growth factor / metabolism*

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