Physical Association of Saccharomyces cerevisiae Polo-like Kinase Cdc5 with Chromosomal Cohesin Facilitates DNA Damage Response

Clicks: 255
ID: 270581
2016
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Abstract
At the onset of anaphase, a protease called separase breaks the link between sister chromatids by cleaving the cohesin subunit Scc1. This irreversible step in the cell cycle is promoted by degradation of the separase inhibitor, securin, and polo-like kinase (Plk) 1-dependent phosphorylation of the S …
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Authors Pakchuen S;Ishibashi M;Takakusagi E;Shirahige K;Sutani T;;
Journal The Journal of biological chemistry
Year 2016
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/27325700
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE pubmed abstract nih national institutes of health national library of medicine mutation cell cycle proteins / genetics cell cycle proteins / metabolism* amino acid substitution saccharomyces cerevisiae / genetics protein-serine-threonine kinases / metabolism* saccharomyces cerevisiae / metabolism* chromosomal proteins protein-serine-threonine kinases / genetics Proto-Oncogene Proteins / metabolism mitosis* proto-oncogene proteins / genetics missense saccharomyces cerevisiae proteins / genetics saccharomyces cerevisiae proteins / metabolism* pmid:27325700 pmc5016123 doi:10.1074/jbc.m116.727438 sujiraporn pakchuen mai ishibashi takashi sutani non-histone / genetics non-histone / metabolism* dna damage* phleomycins / pharmacology phosphorylation / genetics

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