Direct correlation between MUC18 expression and metastatic potential of human melanoma cells

Clicks: 319
ID: 270522
1993
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Popular

Ranked #2 of 4 articles by views in melanoma research

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
The expression of the glycoprotein MUC18 in melanoma biopsies has previously been shown to increase with increasing tumour thickness, and thus to correlate with the probability of metastasis development. We have examined the expression of this molecule by nine human melanoma cell lines with known metastatic ability (both spontaneous and experimental) in nude mice. Examination of the expression of both the MUC18 mRNA and of the glycoprotein on the cell surface revealed a statistically significant correlation (P = 0.040) between its expression and the ability to form metastases in vivo. Although MUC18 shows sequence similarity to neural cell adhesion molecules, no correlation was observed between the site of origin of the metastatic lesions (brain, lymph node) and MUC18 expression.
Reference Key
bar-ell1993melanomadirect Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors M. Luca,B. Hunt,C. D. Bucana,J. P. Johnson,I. J. Fidler,M. Bar-Ell;M. Luca;B. Hunt;C. D. Bucana;J. P. Johnson;I. J. Fidler;M. Bar-Ell;
Journal melanoma research
Year 1993
DOI
10.1097/00008390-199304000-00006
URL
https://sciprofiles.com/publication/view/15d36535ad45926e191a75cad55d8d8c
Keywords
melanoma metastasis metastatic glycoprotein molecules cell neural muc18 expression

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.