A common human skin tumour is caused by activating mutations in beta-catenin

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ID: 270505
1999
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Abstract
WNT signalling orchestrates a number of developmental programs. In response to this stimulus, cytoplasmic beta-catenin (encoded by CTNNB1) is stabilized, enabling downstream transcriptional activation by members of the LEF/TCF family. One of the target genes for beta-catenin/TCF encodes c-MYC, expla …
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ef1999naturea Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Chan EF;Gat U;McNiff JM;Fuchs E;;
Journal nature genetics
Year 1999
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/10192393
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't amino acid sequence P.H.S. DNA Sequence Analysis polymerase chain reaction Molecular Sequence Data transcription factors / metabolism mutation* dna-binding proteins / metabolism trans-activators* beta catenin lymphoid enhancer-binding factor 1 gene frequency deoxyribonucleases pmid:10192393 doi:10.1038/7747 e f chan u gat e fuchs cytoskeletal proteins / genetics* dna-binding proteins / analysis type ii site-specific / genetics hair diseases / genetics* hair diseases / pathology pilomatrixoma / genetics* pilomatrixoma / pathology skin neoplasms / genetics* skin neoplasms / pathology transcription factors / analysis

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