Mdm2 promotes the rapid degradation of p53

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ID: 270407
1997
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Abstract
The p53 tumour-suppressor protein exerts antiproliferative effects, including growth arrest and apoptosis, in response to various types of stress. The activity of p53 is abrogated by mutations that occur frequently in tumours, as well as by several viral and cellular proteins. The Mdm2 oncoprotein i …
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Authors Haupt Y;Maya R;Kazaz A;Oren M;;
Journal Nature
Year 1997
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/9153395
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice RNA animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't P.H.S. Cultured messenger / metabolism recombinant fusion proteins / genetics hela cells transfection protein binding tumor cells recombinant fusion proteins / metabolism nuclear proteins* proto-oncogene proteins / metabolism* proto-oncogene proteins c-mdm2 tumor suppressor protein p53 / metabolism* proto-oncogene proteins / genetics tumor suppressor protein p53 / genetics pmid:9153395 doi:10.1038/387296a0 y haupt r maya m oren down-regulation / radiation effects tumor suppressor protein p53 / antagonists & inhibitors

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