Repair of large segmental bone defects: BMP-2 gene activated muscle grafts vs. autologous bone grafting

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ID: 270369
2013
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Abstract
Common cell based strategies for the treatment of osseous defects require the isolation and expansion of autologous cells. Since this makes such approaches time-consuming and expensive, we developed a novel expedited technology creating gene activated muscle grafts. We have previously shown that large segmental bone defects in rats can be regenerated by implantation of muscle tissue fragments activated by BMP-2 gene transfer.
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müller2013bmcrepair Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Oliver B Betz,Volker M Betz,Christian Schröder,Rainer Penzkofer,Michael Göttlinger,Susanne Mayer-Wagner,Peter Augat,Volkmar Jansson,Peter E Müller;Oliver B Betz;Volker M Betz;Christian Schröder;Rainer Penzkofer;Michael Göttlinger;Susanne Mayer-Wagner;Peter Augat;Volkmar Jansson;Peter E Müller;
Journal bmc biotechnology
Year 2013
DOI
10.1186/1472-6750-13-65
URL
https://sciprofiles.com/publication/view/315de0d0299a08819d769382db675c25
Keywords
tissue engineering gene transfer in vivo bone regeneration bmp-2 large bone defects muscle grafts autologous bone grafts

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