Improved column-based radiochemical processing of the generator produced 68Ga

Clicks: 170
ID: 270271
2011
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Abstract
An improved chemical strategy for processing of the generator produced 68Ga was developed based on processing of the original 68Ge/68Ga generator eluate on a micro-column. Direct pre-concentration and purification of the eluted 68Ga is performed on a cation-exchange resin in hydrochloric acid/acetone media. A supplementary step based on a second micro-column filled with a second resin allows direct re-adsorption of 68Ga eluted from the cation exchanger. 68Ga is finally striped from the second resin with a small volume of pure water. For this purpose a strong anion exchanger and a novel extraction chromatographic resin based on tetraalkyldiglycolamides are characterized. The strategy allows online pre-concentration and purification of 68Ga from the original generator eluate. The supplementary column allows transferring 68Ga with high radionuclide and chemical quality in the aqueous solution with small volume and low acidity useful for direct radiolabeling reactions.
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Authors N.S. Loktionova,A.N. Belozub,D.V. Filosofov,K.P. Zhernosekov,T. Wagner,Andreas Türler,F. Rösch;N.S. Loktionova;A.N. Belozub;D.V. Filosofov;K.P. Zhernosekov;T. Wagner;Andreas Türler;F. Rösch;
Journal applied radiation and isotopes
Year 2011
DOI
10.1016/j.apradiso.2011.02.035
URL
https://sciprofiles.com/publication/view/68003bada2caf21ba2a8653d94fe35ea
Keywords
pet radiolabeling 68ga radionuclide generator post-processing of eluates

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