Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers

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Abstract
To identify new immortalizing genes with potential roles in tumorigenesis, we performed a genetic screen aimed to bypass the rapid and tight senescence arrest of primary fibroblasts deficient for the oncogene Bmi1. We identified the T-box member TBX2 as a potent immortalizing gene that acts by downr …
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jj2000naturesenescence Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jacobs JJ;Keblusek P;Robanus-Maandag E;Kristel P;Lingbeek M;Nederlof PM;van Welsem T;van de Vijver MJ;Koh EY;Daley GQ;van Lohuizen M;;
Journal nature genetics
Year 2000
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/11062467
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE genetic Mice gene expression regulation animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't female P.H.S. Cells Cultured Genes neoplastic* human Fibroblasts / metabolism Promoter Regions protein biosynthesis* carrier proteins / genetics chromosomes transfection proteins / genetics tumor cells cell transformation oncogenes fibroblasts / cytology breast neoplasms / genetics* cell cycle proteins / genetics nuclear proteins / genetics dna-binding proteins* gene deletion Tumor Suppressor Protein p14ARF cell cycle proteins / physiology* neoplasm proteins / genetics neoplastic / genetics proto-oncogene proteins / genetics j j jacobs m van lohuizen polycomb repressive complex 1 adenocarcinoma / metabolism transcription factors / antagonists & inhibitors repressor proteins / genetics pmid:11062467 doi:10.1038/81583 p keblusek adenocarcinoma / genetics* breast neoplasms / metabolism cos cells cell cycle proteins / isolation & purification cellular senescence / genetics* pair 17 / genetics* cyclin-dependent kinase inhibitor p16 e2f transcription factors e2f1 transcription factor gene amplification* brca1 neoplasm proteins / biosynthesis neoplasm proteins / isolation & purification neoplasm proteins / physiology* neoplastic syndromes hereditary / genetics proto-oncogene proteins c-myc / antagonists & inhibitors proto-oncogene proteins p21(ras) / antagonists & inhibitors repressor proteins / isolation & purification repressor proteins / physiology* retinoblastoma-binding protein 1 t-box domain proteins / genetics t-box domain proteins / isolation & purification t-box domain proteins / physiology* transcription factor dp1

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