Dickkopf-1 expression increases early in prostate cancer development and decreases during progression from primary tumor to metastasis

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ID: 270207
2008
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Abstract
Taken together, these data demonstrate that elevated DKK-1 expression is an early event in PCa and that as PCa progresses DKK-1 expression declines, particularly in advanced bone metastases. The decline of DKK-1 in bone metastases can unmask Wnts' osteoblastic activity. These data support a model in …
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Authors Hall CL;Daignault SD;Shah RB;Pienta KJ;Keller ET;;
Journal the prostate
Year 2008
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18561248
Keywords
biopsy National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine prognosis research support male N.I.H. Extramural Retrospective Studies biomarkers disease progression kaplan-meier estimate beta catenin / metabolism Intercellular Signaling Peptides and Proteins / metabolism* bone neoplasms / metabolism prostatic neoplasms / metabolism* prostatic neoplasms / pathology pmid:18561248 pmc3260942 doi:10.1002/pros.20805 christopher l hall stephanie d daignault evan t keller tumor / metabolism* bone neoplasms / secondary liver neoplasms / metabolism liver neoplasms / secondary lung neoplasms / metabolism lung neoplasms / secondary neoplasm metastasis* prostatic neoplasms / diagnosis soft tissue neoplasms / secondary tissue array analysis

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