Brainstem melanomas presenting as a cavernous malformation

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ID: 270200
2014
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Abstract
Melanoma lesions in the brainstem can be difficult to distinguish radiographically and clinically from cavernous malformations. However, the treatment modalities and clinical course of these two diseases differ considerably. We report two cases of melanoma presenting as brainstem hemorrhages. A 69-year-old male was found to have a hemorrhagic lesion of the right dorsal midbrain. After a repeat hemorrhage, the lesion was resected and found to be hyperchromatic. Nonetheless, the patient suffered rebleeding and died 3 months later. A 62-year-old female was similarly found to have an acute pontine hemorrhage. After resection of the lesion, she underwent whole-brain radiation therapy but ultimately died 5.5 months later. The histopathology of both lesions was consistent with melanoma. Melanoma in the brainstem can mimic cavernous malformations. While management of these lesions includes stereotactic radiosurgery, whole-brain radiation, and surgical resection, metastatic brainstem melanoma follows an aggressive clinical course with a poor prognosis.
Reference Key
bulsara2014neurochirurgiebrainstem Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors A.Y. Lu,A.R. Patel,G.A. Kuzmik,K.-K. Atsina,R.A. Bronen,P.M. Jabbour,David Hasan,A.O. Vortmeyer,B.G. Welch,K.R. Bulsara;A.Y. Lu;A.R. Patel;G.A. Kuzmik;K.-K. Atsina;R.A. Bronen;P.M. Jabbour;David Hasan;A.O. Vortmeyer;B.G. Welch;K.R. Bulsara;
Journal neurochirurgie
Year 2014
DOI
10.1016/j.neuchi.2014.02.005
URL
https://sciprofiles.com/publication/view/c336054302d8a26fc197f3cba4461f1b
Keywords
melanoma brain stem cavernous malformations of cns and retina malformations caverneuses du système nerveux central et de la rétine mélanome tronc cérébral

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