Current State of SLC and ABC Transporters in the Skin and Their Relation to Sweat Metabolites and Skin Diseases

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ID: 270168
2021
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Abstract
With a relatively large surface area (2 m2) and 15% of total body mass, the skin forms the largest organ of the human body. The main functions of the skin include regulation of body temperature by insulation or sweating, regulation of the nervous system, regulation of water content, and protection against external injury. To perform these critical functions, the skin encodes genes for transporters responsible for the cellular trafficking of essential nutrients and metabolites to maintain cellular hemostasis. However, the knowledge on the expression, regulation, and function of these transporters is very limited and needs more work to elucidate how these transporters play a role both in disease progression and in healing. Furthermore, SLC and ABC transporters are understudied, and even less studied in skin. There are sparse reports on relation between transporters in skin and sweat metabolites. This mini review focuses on the current state of SLC and ABC transporters in the skin and their relation to sweat metabolites and skin diseases.
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hughes2021proteomescurrent Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Marcus M. K. Hughes;Eva Aryal;Elnaz Safari;Biljana Mojsoska;Håvard Jenssen;Bala Krishna Prabhala;Hughes, Marcus M. K.;Aryal, Eva;Safari, Elnaz;Mojsoska, Biljana;Jenssen, Håvard;Prabhala, Bala Krishna;
Journal proteomes
Year 2021
DOI
10.3390/proteomes9020023
URL
https://www.mdpi.com/2227-7382/9/2/23
Keywords
skin diseases abc transporters sweat metabolites slc transporters skin transporters knime

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