Synthesis of Novel IP Agonists via N-Aminoethyl Cyclic Amines Prepared by Decarboxylative Ring-Opening Reactions

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ID: 270107
2012
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Abstract
An efficient synthesis of a highly potent and selective IP (PGI2 receptor) agonist that is not structurally analogous to PGI2 is described. This synthesis is accomplished through the following key steps: Nucleophilic ring-opening of 3-(4-chlorophenyl)-oxazolidin-2-one prepared by a one-pot procedure with 4-piperidinol and selective O-alkylation of 1-(2-(4-chlorophenylamino)ethyl)piperidin-4-ol. The obtained compound is a potent and selective IP agonist displaying a long duration of action.
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Authors Yasuhiro Morita;Takeshi Ishigaki;Kuniaki Kawamura;Ryoji Hayashi;Masafumi Isogaya;Mika Kitsukawa;Mitsuko Miyamoto;Masashi Uchida;Katsuhiko Iseki;Morita, Yasuhiro;Ishigaki, Takeshi;Kawamura, Kuniaki;Hayashi, Ryoji;Isogaya, Masafumi;Kitsukawa, Mika;Miyamoto, Mitsuko;Uchida, Masashi;Iseki, Katsuhiko;
Journal molecules
Year 2012
DOI
10.3390/molecules17021233
URL
https://doi.org/10.3390/molecules17021233
Keywords
heterocycles amines piperidines anilines ip agonists heterocycles amines piperidines anilines ip agonists

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