Changes of metal contents and isometallothionein levels in rat tissues after cadmium loading
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ID: 269834
1980
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Abstract
Concentrations of metals (Cd, Zn, Cu and Fe) in serum, liver and kidneys changed with time after a single injection of cadmium chloride into rats. The injected cadmium disappeared from serum within 6hr and transferred mainly to liver. Distribution patterns of cadmium, zinc and copper in the tissue supernatant fractions were investigated mainly on a SW 3000 column (which was connected to a high speed liquid Chromatograph with a flame atomic absorption spectrophotometer) and also on a Sephadex G-75 column. Cadmium in the liver supernatant fractions changed distributions among protein fractions with time and was mostly present as metallothionein 6hr after the injection. The ratios of both metallothionein-I/-II and Cd/Zn in each isometallothionein changed with time, which suggested active degradation and resynthesis of metallothionein in the liver regardless of the constant metallothionein level. Cadmium in the kidney supernatant fractions increased slowly but consecutively with time and was present mostly as three isometallothioneins on a SW column due to high copper content.
| Reference Key |
mitsuru1980biochemicalchanges
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| Authors | Kazuo T. Suzuki,M Yamamura,Yamamura Mitsuru;Kazuo T. Suzuki;M Yamamura;Yamamura Mitsuru; |
| Journal | biochemical pharmacology |
| Year | 1980 |
| DOI |
10.1016/0006-2952(80)90342-1
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