Pyranopyran-1,8-dione, an Active Compound from Vitices Fructus, Attenuates Cigarette-Smoke Induced Lung Inflammation in Mice

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ID: 269785
2017
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Abstract
Previously, we isolated and identified pyranopyran-1,8-dione (PPY) from Viticis Fructus, as a bioactive compound possessing anti-inflammatory properties. The present study was aimed to evaluate the preventive benefit of PPY on cigarette–smoke (CS)-induced lung inflammation. C57BL/6 mice were exposed to CS for 2 weeks while PPY was administrated by oral injection 2 h before CS exposure. To validate the anti-inflammatory effects of PPY, the numbers of immune cells in the bronchoalveolar lavage fluid were counted. Proinflammatory cytokines (Tumor necrosis factor-α: TNF-α, IL-6) and keratinocyte chemokine (KC/CXCL1) were also measured. Histopathologic analysis and cellular profiles showed that inflammatory cell infiltrations were significantly decreased in peribronchial and perivascular area by PPY treatment. The alveolar destruction by CS was markedly ameliorated by PPY treatment. In addition, the TNF-α, IL-6, and KC levels were declined in the PPY groups. These observations suggest that PPY has a preventive potential for lung inflammatory diseases.
Reference Key
lee2017internationalpyranopyran-1,8-dione, Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gihyun Lee;Kyung-Hwa Jung;Eun Seok Ji;Hyunsu Bae;Lee, Gihyun;Jung, Kyung-Hwa;Ji, Eun Seok;Bae, Hyunsu;
Journal International journal of molecular sciences
Year 2017
DOI
10.3390/ijms18071602
URL
https://doi.org/10.3390/ijms18071602
Keywords
phytochemical inflammation lung cigarette smoke viticis fructus pyranopyran-1 8-dione

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