Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice

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ID: 269774
2002
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Abstract
T cell development and selection require the fully mature and diverse epithelial microenvironment of the thymus. Acquisition of these characteristics is dependent on expression of the forkhead (also known as winged-helix) transcription factor FoxN1, as a lack of functional FoxN1 results in aberrant …
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Authors Balciunaite G;Keller MP;Balciunaite E;Piali L;Zuklys S;Mathieu YD;Gill J;Boyd R;Sussman DJ;Holländer GA;;
Journal Nature Immunology
Year 2002
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/12379851
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE genetic Mice Post-Translational animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't protein biosynthesis Genes 3T3 Cells Receptors DNA-Binding Proteins / deficiency Gene Expression Regulation* Recombinant Fusion Proteins / physiology transcription enzyme inhibitors / pharmacology cell differentiation phosphoinositide-3 kinase inhibitors nude transcription factors / physiology* phosphoproteins / biosynthesis dna-binding proteins / genetics transcription factors / genetics proteins / genetics phosphorylation reporter protein processing epithelial cells / metabolism phosphoproteins / genetics adaptor proteins signal transducing glycoproteins / genetics transcription factor 7-like 2 protein xenopus proteins* cell surface / genetics proto-oncogene proteins / physiology* proto-oncogene proteins c-akt wnt proteins beta catenin Proto-Oncogene Proteins / metabolism cell surface / biosynthesis lymphoid enhancer-binding factor 1 forkhead transcription factors proto-oncogene proteins / genetics wnt4 protein transcription factors / biosynthesis* paracrine communication wnt3 protein zebrafish proteins* trans-activators / genetics morphogenesis proteins / physiology* glycoproteins / physiology* pmid:12379851 doi:10.1038/ni850 gina balciunaite marcel p keller georg a holländer autocrine communication chromones / pharmacology cytoskeletal proteins / biosynthesis cytoskeletal proteins / genetics dna-binding proteins / biosynthesis* dishevelled proteins epithelial cells / ultrastructure frizzled receptors glycoproteins / biosynthesis lymphopoiesis / genetics* morpholines / pharmacology phosphatidylinositol 3-kinases / physiology protein-serine-threonine kinases* proto-oncogene proteins / biosynthesis g-protein-coupled* t-lymphocytes / cytology* tcf transcription factors thymus gland / cytology thymus gland / metabolism trans-activators / biosynthesis transcription factors / deficiency

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