Uptake of chloroquine and hydroxychloroquine by human blood leucocytes in vitro: relation to cellular concentrations during antirheumatic therapy

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ID: 269730
1987
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Abstract
The accumulation of chloroquine and hydroxychloroquine in unfractionated mononuclear cells and in purified monocytes, lymphocytes, and neutrophil polymorphonuclear leucocytes (PMN) was measured in vitro. Accumulation of both drugs in leucocytes was time and dose dependent. Cellular levels comparable …
Reference Key
jk1987annalsuptake Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors French JK;Hurst NP;O'Donnell ML;Betts WH;;
Journal annals of the rheumatic diseases
Year 1987
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/3813674
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't in vitro techniques arthritis cell survival rheumatoid / blood* pmid:3813674 pmc1002056 doi:10.1136/ard.46.1.42 j k french n p hurst w h betts rheumatoid / drug therapy chloroquine / blood* hydroxychloroquine / blood hydroxychloroquine / therapeutic use leukocytes / metabolism*

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