Uptake of chloroquine and hydroxychloroquine by human blood leucocytes in vitro: relation to cellular concentrations during antirheumatic therapy
Clicks: 204
ID: 269730
1987
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Abstract
The accumulation of chloroquine and hydroxychloroquine in unfractionated mononuclear cells and in purified monocytes, lymphocytes, and neutrophil polymorphonuclear leucocytes (PMN) was measured in vitro. Accumulation of both drugs in leucocytes was time and dose dependent. Cellular levels comparable …
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| Authors | French JK;Hurst NP;O'Donnell ML;Betts WH;; |
| Journal | annals of the rheumatic diseases |
| Year | 1987 |
| DOI |
DOI not found
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| URL | |
| Keywords |
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
in vitro techniques
arthritis
cell survival
rheumatoid / blood*
pmid:3813674
pmc1002056
doi:10.1136/ard.46.1.42
j k french
n p hurst
w h betts
rheumatoid / drug therapy
chloroquine / blood*
hydroxychloroquine / blood
hydroxychloroquine / therapeutic use
leukocytes / metabolism*
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