A novel method for SNP detection using a new duplex-specific nuclease from crab hepatopancreas
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ID: 269716
2002
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Abstract
We have characterized a novel nuclease from the Kamchatka crab, designated duplex-specific nuclease (DSN). DSN displays a strong preference for cleaving double-stranded DNA and DNA in DNA-RNA hybrid duplexes, compared to single-stranded DNA. Moreover, the cleavage rate of short, perfectly matched DN …
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da2002genomea
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| Authors | Shagin DA;Rebrikov DV;Kozhemyako VB;Altshuler IM;Shcheglov AS;Zhulidov PA;Bogdanova EA;Staroverov DB;Rasskazov VA;Lukyanov S;; |
| Journal | genome research |
| Year | 2002 |
| DOI |
DOI not found
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| Keywords |
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
animals
pubmed abstract
nih
national institutes of health
national library of medicine
models
research support
non-u.s. gov't
Molecular Sequence Data
Polymorphism
endonucleases / genetics*
cloning
single nucleotide / genetics*
liver / enzymology
pmid:12466298
pmc187582
doi:10.1101/gr.547002
dmitry a shagin
denis v rebrikov
sergey lukyanov
anomura / enzymology*
anomura / genetics*
molecular / methods
nucleic acid heteroduplexes / genetics*
oligonucleotides / chemical synthesis
oligonucleotides / metabolism
pancreas / enzymology
substrate specificity / genetics
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