Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia
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ID: 269645
2019
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Abstract
Background Methotrexate (MTX) is an important anti-folate agent in pediatric acute lymphoblastic leukemia (ALL) treatment. Folinic acid rescue therapy (Leucovorin) is administered after MTX to reduce toxicity. Previous studies hypothesized that Leucovorin could ‘rescue’ both normal healthy cells and leukemic blasts from cell death. We assessed whether Leucovorin is able to restore red blood cell folate levels after MTX. Methods We prospectively determined erythrocyte folate levels (5-methyltetrahydrofolate (THF) and non-methyl THF) and serum folate levels in 67 children with ALL before start (T0) and after stop (T1) of HD-MTX and Leucovorin courses. Results Erythrocyte folate levels increased between T0 and T1 (mean ± SD: 416.7 ± 145.5 nmol/L and 641.2 ± 196.3 nmol/L respectively, p
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| Reference Key |
oosterom2019ploschanges
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|---|---|
| Authors | Natanja Oosterom;Robert de Jonge;Desiree E. C. Smith;Rob Pieters;Wim J. E. Tissing;Marta Fiocco;Bertrand D. van Zelst;Marry M. van den Heuvel-Eibrink;Sandra G. Heil; |
| Journal | PloS one |
| Year | 2019 |
| DOI |
10.1371/journal.pone.0221591
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| URL | |
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