Ghrelin is a growth-hormone-releasing acylated peptide from stomach - Nature

Clicks: 244
ID: 269501
1970
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Popular

Ranked #153 of 375 articles by views in Nature

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 375 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Small synthetic molecules called growth-hormone secretagogues (GHSs)1,2,3 stimulate the release of growth hormone (GH) from the pituitary4,5. They act through GHS-R, a G-protein-coupled receptor for which the ligand is unknown. Recent cloning of GHS-R6,7 strongly suggests that an endogenous ligand for the receptor does exist and that there is a mechanism for regulating GH release that is distinct from its regulation by hypothalamic growth-hormone-releasing hormone (GHRH)4,5. We now report the purification and identification in rat stomach of an endogenous ligand specific for GHS-R. The purified ligand is a peptide of 28 amino acids, in which the serine 3 residue is n-octanoylated. The acylated peptide specifically releases GH both in vivo and in vitro, and O-n-octanoylation at serine 3 is essential for the activity. We designate the GH-releasing peptide ‘ghrelin’ (ghre is the Proto-Indo-European root of the word ‘grow’). Human ghrelin is homologous to rat ghrelin apart from two amino acids. The occurrence of ghrelin in both rat and human indicates that GH release from the pituitary may be regulated not only by hypothalamic GHRH, but also by ghrelin.
Reference Key
masayasu1970natureghrelin Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kojima, Masayasu;Hosoda, Hiroshi;Date, Yukari;Nakazato, Masamitsu;Matsuo, Hisayuki;Kangawa, Kenji;Kojima, Masayasu;Hosoda, Hiroshi;Date, Yukari;Nakazato, Masamitsu;Matsuo, Hisayuki;Kangawa, Kenji;
Journal Nature
Year 1970
DOI
doi:10.1038/45230
URL
http://dx.doi.org/10.1038/45230
Keywords
Science humanities and social sciences multidisciplinary

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.