Central Conduction Time in Childhood Autism

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ID: 269472
1992
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Abstract
To investigate the integrity of the brain-stem in 20 mentally handicapped children who met the Rutter criteria for autism, brain-stem auditory evoked potentials were obtained for a range of stimulus intensities. Central conduction times (CCTs) were calculated for the Wave l–Wave V interval of the brain-stem potentials. In children under 14 years of age CCTs were normal. In children 14 years of age and over, three of four girls and eight of nine boys had CCTs exceeding normal limits when compared with a group of controls of normal intelligence, matched for age and sex. CCTs recorded from a group of non-autistic mentally handicapped children were within normal limits. The age distributions are consistent with a maturational defect in myelination within the brain-stem in autism, a defect which may have a much wider anatomical distribution throughout cortical and subcortical structures.
Reference Key
sherrard1992thecentral Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors R. J. McClelland,D. G. Eyre,D. Watson,G. J. Calvert,Eileen Sherrard;R. J. McClelland;D. G. Eyre;D. Watson;G. J. Calvert;Eileen Sherrard;
Journal the british journal of psychiatry
Year 1992
DOI
10.1192/bjp.160.5.659
URL
https://sciprofiles.com/publication/view/16b914547b45b7681e6506156596204f
Keywords
autism brain stem defect mentally handicapped children

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