A role for the cytoplasmic polyadenylation element in NMDA receptor-regulated mRNA translation in neurons

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ID: 269452
2001
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Abstract
The ability of neurons to modify synaptic connections based on activity is essential for information processing and storage in the brain. The induction of long-lasting changes in synaptic strength requires new protein synthesis and is often mediated by NMDA-type glutamate receptors (NMDARs). We used …
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Authors Wells DG;Dong X;Quinlan EM;Huang YS;Bear MF;Richter JD;Fallon JR;;
Journal The Journal of neuroscience : the official journal of the Society for Neuroscience
Year 2001
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/11739565
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE RNA animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't Neuronal Plasticity / physiology P.H.S. Cells Cultured Rats Receptors Messenger / genetics green fluorescent proteins luminescent proteins / genetics neurons / drug effects regulatory sequences transfection neurons / metabolism* messenger / metabolism* glutamic acid / pharmacology gene expression regulation / physiology synapses / physiology visual cortex / cytology pmid:11739565 pmc6763028 doi:10.1523/jneurosci.21-24-09541.2001 d g wells x dong j r fallon 3' untranslated regions / genetics 3' untranslated regions / metabolism calcium-calmodulin-dependent protein kinase type 2 calcium-calmodulin-dependent protein kinases / genetics calcium-calmodulin-dependent protein kinases / metabolism darkness excitatory amino acid agonists / pharmacology luminescent proteins / biosynthesis neurons / cytology photic stimulation / methods polyadenylation / drug effects protein biosynthesis / physiology* long-evans n-methyl-d-aspartate / agonists n-methyl-d-aspartate / antagonists & inhibitors n-methyl-d-aspartate / metabolism* nucleic acid / physiology* sensory deprivation / physiology visual cortex / metabolism

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