Hydrogel as a Biomaterial for Bone Tissue Engineering: A Review

水凝胶作为骨组织工程生物材料：综述

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ID: 269431
2020
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Abstract
Severe bone damage from diseases, including extensive trauma, fractures, and bone tumors, cannot self-heal, while traditional surgical treatment may bring side effects such as infection, inflammation, and pain. As a new biomaterial with controllable mechanical properties and biocompatibility, hydrogel is widely used in bone tissue engineering (BTE) as a scaffold for growth factor transport and cell adhesion. In order to make hydrogel more suitable for the local treatment of bone diseases, hydrogel preparation methods should be combined with synthetic materials with excellent properties and advanced technologies in different fields to better control drug release in time and orientation. It is necessary to establish a complete method to evaluate the hydrogel’s properties and biocompatibility with the human body. Moreover, establishment of standard animal models of bone defects helps in studying the therapeutic effect of hydrogels on bone repair, as well as to evaluate the safety and suitability of hydrogels. Thus, this review aims to systematically summarize current studies of hydrogels in BTE, including the mechanisms for promoting bone synthesis, design, and preparation; characterization and evaluation methods; as well as to explore future applications of hydrogels in BTE.
由大范围创伤、骨折和骨肿瘤等疾病导致的严重骨损伤无法自愈，而传统手术治疗可能会带来感染、炎症和疼痛等副作用。作为一种具有可控力学性能和生物相容性的新型生物材料，水凝胶在骨组织工程（BTE）中被广泛用作生长因子递送和细胞黏附的支架。为了使水凝胶更适用于骨疾病的局部治疗，水凝胶的制备方法应与具有优良性能的合成材料以及不同领域的先进技术相结合，以更好地在时间和方向上控制药物释放。同时，有必要建立一套完整的方法来评估水凝胶的各项性能及其与人体的生物相容性。此外，建立标准化的骨缺损动物模型有助于研究水凝胶对骨修复的治疗效果，并评估其安全性和适用性。因此，本综述旨在系统总结当前水凝胶在BTE中的研究进展，包括促进骨形成的机制、设计与制备、表征与评估方法，并探讨水凝胶在BTE领域的未来应用前景。
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yue2020nanomaterialshydrogel Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Shuai Yue;Hui He;Bin Li;Tao Hou;Yue, Shuai;He, Hui;Li, Bin;Hou, Tao;
Journal Nanomaterials
Year 2020
DOI
10.3390/nano10081511
URL
https://www.mdpi.com/2079-4991/10/8/1511
Keywords
mechanism design hydrogels bone tissue engineering evaluation methods

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