Determinants of amikacin first peak concentration in critically ill patients

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ID: 269429
2018
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Abstract
Amikacin antimicrobial effect has been correlated with the ratio of the peak concentration (Cmax ) to the minimum inhibitory concentration. A target Cmax ≥ 60-80 mg/L has been suggested. It has been shown that such target is not achieved in a large proportion of critically ill …
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Authors Boidin C;Jenck S;Bourguignon L;Torkmani S;Roussey-Jean A;Ledochowski S;Marry L;Ammenouche N;Dupont H;Marçon F;Allaouchiche B;Bohé J;Lepape A;Goutelle S;Friggeri A;;
Journal fundamental & clinical pharmacology
Year 2018
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/29660162
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine female male middle aged regression analysis Retrospective Studies microbial sensitivity tests intensive care units anti-bacterial agents / therapeutic use* critical illness amikacin / therapeutic use* pmid:29660162 doi:10.1111/fcp.12374 clément boidin sophie jenck arnaud friggeri

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