Regulation of p53 stability by Mdm2

تنظيم استقرار p53 بواسطة Mdm2

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ID: 269406
1997
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Abstract
The tumour-suppressor p53 is a short-lived protein that is maintained at low, often undetectable, levels in normal cells. Stabilization of the protein in response to an activating signal, such as DNA damage, results in a rapid rise in p53 levels and subsequent inhibition of cell growth. Tight regula …
يُعد البروتين الكابح للأورام p53 بروتينًا قصير العمر، ويُحافظ عليه عند مستويات منخفضة، غالبًا ما يتعذر الكشف عنها، في الخلايا الطبيعية. ويؤدي استقرار البروتين استجابةً لإشارة مُنَشِّطة، مثل تلف الحمض النووي (DNA)، إلى ارتفاع سريع في مستويات p53 وما يعقب ذلك من تثبيط لنمو الخلايا. والتنظيم الدقيق …
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mh1997natureregulation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kubbutat MH;Jones SN;Vousden KH;;
Journal Nature
Year 1997
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/9153396
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE genetic Mice gene expression regulation animals humans pubmed abstract nih national institutes of health national library of medicine research support u.s. gov't P.H.S. Cultured cell line mutation transcription transfection tumor cells nuclear proteins* proteasome endopeptidase complex proto-oncogene proteins / metabolism* proto-oncogene proteins c-mdm2 tumor suppressor protein p53 / metabolism* proto-oncogene proteins / genetics pmid:9153396 doi:10.1038/387299a0 m h kubbutat s n jones k h vousden acetylcysteine / analogs & derivatives acetylcysteine / pharmacology cysteine endopeptidases / metabolism cysteine proteinase inhibitors / pharmacology multienzyme complexes / metabolism tumor suppressor protein p53 / genetics

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