Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.
Clicks: 146
ID: 269280
1997
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Abstract
We have produced transgenic mice whose livers express a dominant positive NH2-terminal fragment of sterol regulatory element binding protein-1c (SREBP-1c). Unlike full-length SREBP-1c, the NH2-terminal fragment enters the nucleus without a requirement ...
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goldstein1997journalisoform
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| Authors | H Shimano, J D Horton, I Shimomura, R E Hammer, M S Brown, J L Goldstein;H Shimano;J D Horton;I Shimomura;R E Hammer;M S Brown;J L Goldstein; |
| Journal | Journal of Clinical Investigation |
| Year | 1997 |
| DOI |
10.1172/JCI119248
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