AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor

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ID: 269231
2001
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Abstract
The central melanocortin (MC) system has been demonstrated to act downstream of leptin in the regulation of body weight. The system comprises alpha-MSH, which acts as agonist, and agouti-related protein (AgRP), which acts as antagonist at the MC3 and MC4 receptors (MC3R and MC4R). This property sugg …
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Authors Nijenhuis WA;Oosterom J;Adan RA;;
Journal Molecular endocrinology (Baltimore, Md.)
Year 2001
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/11145747
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't cell line Receptors proteins / pharmacology* receptor agouti-related protein intercellular signaling peptides and proteins peptide fragments / pharmacology* pmid:11145747 doi:10.1210/mend.15.1.0578 w a nijenhuis j oosterom r a adan adenylyl cyclases / metabolism colforsin / pharmacology melanocortin type 4 corticotropin / agonists* corticotropin / drug effects* corticotropin / physiology alpha-msh / pharmacology

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