A camel-derived MERS-CoV with a variant spike protein cleavage site and distinct fusion activation properties

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2016
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Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) continues to circulate in both humans and camels, and the origin and evolution of the virus remain unclear. Here we characterize the spike protein of a camel-derived MERS-CoV (NRCE-HKU205) identified in 2013, early in the MERS outbreak. NRCE-HK …
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Authors Millet JK;Goldstein ME;Labitt RN;Hsu HL;Daniel S;Whittaker GR;;
Journal emerging microbes & infections
Year 2016
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/27999426
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals humans pubmed abstract nih national institutes of health national library of medicine cell line pmid:27999426 pmc5180369 doi:10.1038/emi.2016.125 jean kaoru millet monty e goldstein gary r whittaker amino acid substitution* camelus / virology* furin / metabolism isoleucine / genetics middle east respiratory syndrome coronavirus / genetics* middle east respiratory syndrome coronavirus / isolation & purification* middle east respiratory syndrome coronavirus / physiology proteolysis serine / genetics spike glycoprotein coronavirus / genetics* coronavirus / metabolism virus internalization

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