Calcium

Clicks: 200
ID: 269163
2014
Free PDF
Article Quality & Performance Metrics
Overall Quality Improving Quality
0.0 /100
Combines engagement data with AI-assessed academic quality
AI Quality Assessment
Not analyzed
Abstract
Calcium, the most abundant extracellular polyvalent ion, has important intra- and extracellular functions in the nervous system, where it regulates neuronal excitability and stimulus–response coupling. Hypercalcemia causes encephalopathy, myopathic weakness, and focal cerebral dysfunction; hypocalcemia produces encephalopathy, seizures, paresthesia, and tetany. Calcium enters neurons and other cells through voltage-gated and ligand-gated ion channels. Diseases resulting from impaired function of these channels, termed channelopathies, include Lambert–Eaton myasthenic syndrome, hypokalemic periodic paralysis, malignant hyperthermia, familial hemiplegic migraine, episodic ataxia type 2, spinocerebellar ataxia 6, and anti-NMDAR encephalitis. Calcium was discovered in 1808 by Humphry Davy. In 1883, Sidney Ringer showed that calcium was required for myocardial contractility, and Katz and colleagues demonstrated in the 1950s and 1960s that chemical neurotransmission at the neuromuscular junction depended on calcium influx into nerve terminals.
Reference Key
greenberg2014encyclopediacalcium Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors D.A. Greenberg;D.A. Greenberg;
Journal Encyclopedia of the Neurological Sciences
Year 2014
DOI
10.1016/b978-0-12-385157-4.01206-9
URL
https://sciprofiles.com/publication/view/3cdda27ab25960187ea63e999e464042
Keywords
hypercalcemia calcium ion channels voltage-gated calcium channels channelopathies ligand-gated channels type 2 anti-nmdar encephalitis episodic ataxia familial hemiplegic migraine hypocalcemia hypokalemic periodic paralysis lambert–eaton myasthenic syndrome malignant hyperthermia spinocerebellar ataxia 6 tetany

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.