Higher than recommended amikacin loading doses achieve pharmacokinetic targets without associated toxicity

Clicks: 293
ID: 269109
2011
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Abstract
Antibiotic therapy improves the outcome of severe sepsis and septic shock, however pharmacokinetic properties are altered in this scenario. Amikacin (AMK) is an option to treat community or nosocomial infections, although standard doses might be insufficient in critically ill patients. The aim of th …
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Authors Gálvez R;Luengo C;Cornejo R;Kosche J;Romero C;Tobar E;Illanes V;Llanos O;Castro J;;
Journal international journal of antimicrobial agents
Year 2011
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/21612894
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine female male aged middle aged Randomized Controlled Trial sepsis / drug therapy* anti-bacterial agents / administration & dosage* anti-bacterial agents / pharmacokinetics amikacin / adverse effects* anti-bacterial agents / adverse effects* amikacin / administration & dosage* kidney function tests pmid:21612894 doi:10.1016/j.ijantimicag.2011.03.022 ricardo gálvez cecilia luengo josé castro amikacin / pharmacokinetics creatinine / metabolism metabolic clearance rate plasma / chemistry*

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