Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-like Receptor 7/8 Agonistic Immune Modulators
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ID: 269053
2021
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Abstract
Small-molecular Toll-like receptor 7/8 (TLR7/8) agonists hold promise as immune modulators for a variety of immune therapeutic purposes including cancer therapy or vaccination. However, due to their rapid systemic distribution causing difficult-to-control inflammatory off-target effects, their appli …
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| Reference Key |
a2021journalsquaric
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| Authors | Huppertsberg A;Kaps L;Zhong Z;Schmitt S;Stickdorn J;Deswarte K;Combes F;Czysch C;De Vrieze J;Kasmi S;Choteschovsky N;Klefenz A;Medina-Montano C;Winterwerber P;Chen C;Bros M;Lienenklaus S;Sanders NN;Koynov K;Schuppan D;Lambrecht BN;David SA;De Geest BG;Nuhn L;; |
| Journal | Journal of the American Chemical Society |
| Year | 2021 |
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