A case-control auditory evaluation of patients treated with artemisinin derivatives for multidrug-resistant Plasmodium falciparum malaria

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2000
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Abstract
The artemisinin derivatives are now used widely in areas with multidrug-resistant Plasmodium falciparum malaria such as Southeast Asia, but concerns remain over their potential for neurotoxicity. Mice, rats, dogs, and monkeys treated with high doses of intramuscular artemether or arteether develop a …
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Authors Van Vugt M;Angus BJ;Price RN;Mann C;Simpson JA;Poletto C;Htoo SE;Looareesuwan S;White NJ;Nosten F;;
Journal The American journal of tropical medicine and hygiene
Year 2000
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/10761725
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Thailand animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't adult female male adolescent middle aged Child preschool follow-up studies drug resistance multiple case-control studies drug therapy combination malaria antimalarials / therapeutic use plasmodium falciparum / drug effects falciparum / drug therapy* f nosten evoked potentials pmid:10761725 doi:10.4269/ajtmh.2000.62.65 m van vugt b j angus antimalarials / adverse effects* artemether artemisinins* artesunate audiometry auditory brain stem / drug effects* mefloquine / therapeutic use plasmodium falciparum / pathogenicity sesquiterpenes / adverse effects* sesquiterpenes / therapeutic use

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